Thermosensitive hybrid system based on pluronic F127 and nanoclay laponite for sustained local release of lidocaine hydrochloride

Abstract

A novel thermosensitive local drug release system was prepared by incorporation of biocompatible nanoclay laponite into pluronic F127 solution and characterized by rheological measurements, zeta potential measurement and in vitro drug release measurement in the presence of lidocaine hydrochloride. All the systems transited from sol to gel with increase of temperature. The lower critical solution temperature (LCST) of the composite matrix changed little with increase in the mass of incorporated nanoclay, but the modulus increased with increase in the mass of incorporated nanoclay. Thein-vitrorelease experiments revealed that the novel system provided an extended duration of drugs compared to the pluronic F127 alone. This unique feature is attributed to the interaction of nanoclay laponite with lidocaine hydrochloride and increased modulus with incoporation of nanoclay laponite. The merits of the novel system, such as good cytocompatibility, thermosensitive properties, and improved sustained local release ability, make them a promising platform for the delivery of other drugs.