Studying of the Polylactide or Polyglycylidactide Surface Layer Biodegradation in Neutral Media for the Subsequent Layered Composite Creation

  • E О Nasakina
  • A S Baikin
  • M A Kaplan
  • Е A Danilova
  • A A Kolmakova
  • M I Baskakova
  • I M Fedyuk
  • M A Sudarchikova
  • K V Sergiyenko
  • S V Konushkin
  • M A Sevost'yanov
  • A G Kolmakov
Keywords: polylactide, polyglycylidactide, biodegradation, biocompatible material, medical appointment


The processes of biodegradation in phosphate buffer with pH 7.4 and 0.9 wt.% NaCl of polymer polylactide or polyglycylidactide films for the subsequent creation of a layered composite with a biodegradable layer on the basis of a nickel-free shape memory alloy TiNbTaZr were studied. The structure of the samples was determined by SEM and an optical microscope. For polylactide films the rate of biodegradation did not depend on the mass of the film. A gradual decrease in the rate of biodegradation at any mass with a similar dependence on time is noted. With an increase in the mass of films based on poly(glycolide-lactide) the rate of biodegradation increased. And even at the initial stage the dissolution rate is 2-3 times higher than in pure polylactide. On day 180, complete dissolution of the polyglycolidelactide was observed (even a precipitate was not observed) and completely entire polylactide films, however, lost  their transparency, was noted.